Protein Molecular Weight Markers
ABclonal Technology CORIN Rabbit pAb
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology MS4A7 Rabbit pAb
This gene encodes a member of the membrane-spanning 4A gene family, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. This family member is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. This gene is localized to 11q12, in a cluster of other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed.
ABclonal Technology ALDH1L2 Rabbit pAb
This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.
Meso Scale Discovery PhosphoThr231/Tau TTL20 Plate
The Meso Scale Discovery Phospho-Thr231/Total Tau Kit is a multiplex immunoassay kit that allows for the simultaneous measurement of phosphorylated Thr231 tau and total tau in biological samples such as CSF serum plasma cell lysates and brain homogenates The kit contains a 96-well plate coated with capture antibodies specific for phosphorylated Thr231 tau and total tau It utilizes MSD s electrochemiluminescence detection technology to provide sensitive and accurate quantification of both analytes from a single small sample volume The kit includes all necessary reagents and can process up to 80 samples in duplicate It is suitable for studying Alzheimer s disease and other tauopathies
ABclonal Technology TCEA1 Rabbit pAb
Predicted to enable DNA binding activity, translation elongation factor activity, and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within erythrocyte differentiation and positive regulation of transcription, DNA-templated. Located in nucleolus and nucleoplasm. Part of transcription factor TFIID complex.
ABclonal Technology Sterol carrier protein 2 Rabbit mAb
This gene encodes two proteins sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.
ABclonal Technology PCDH1 Rabbit pAb
This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracelllular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene.
Sigma Aldrich Fine Chemicals Biosciences ECLTM Prime Western Blotti
Amersham(TM) ECL(TM) Prime is a highly sensitive reagent characterized by stable signal emission allowing for the possibility of repeated exposures and making it easier to process several blots in the same experimental run. The high intensity of the emitted signals means that proteins can be detected using highly diluted primary and secondary antibodies contributing to low background and reducing consumption of reagents.Amersham(TM) ECL(TM) Prime consolidates and builds on the benefits of Amersham(TM) ECL(TM) Plus and Amersham(TM) ECL(TM) Advance to deliver a detection system that is sensitive stable precisely quantitative across a wide dynamic range of protein levels and conservative in its consumption of expensive antibody reagents.
ABclonal Technology DDX43 Rabbit pAb
The protein encoded by this gene is an ATP-dependent RNA helicase in the DEAD-box family and displays tumor-specific expression.
ABclonal Technology TMC5 Rabbit pAb
Predicted to enable mechanosensitive ion channel activity. Predicted to be involved in ion transmembrane transport. Located in extracellular exosome.
ABclonal Technology RPL7A Rabbit pAb
This gene encodes a ribosomal protein that is a component of the 60S subunit and belongs to the L7AE family of ribosomal proteins. It can interact with nuclear hormone receptors, such as the thyroid hormone receptor, and inhibit their ability to transactivate by preventing binding to DNA response elements. The gene is part of the surfeit gene cluster and is co-transcribed with small nucleolar RNA genes U24, U36a, U36b, and U36c located in its introns. The gene can rearrange with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of ribosomal protein L7a’s N terminus fused to the receptor tyrosine kinase domain of trk. Multiple processed pseudogenes of this gene are dispersed throughout the genome.
ABclonal Technology ITSN2 Rabbit pAb
This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis.
ABclonal Technology ACTR10 Rabbit pAb
Predicted to be involved in retrograde axonal transport of mitochondrion. Predicted to be located in cytosol, extracellular region, and secretory granule. Predicted to be part of dynactin complex.
ABclonal Technology TPMT Rabbit pAb
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.
ABclonal Technology ORC3 Rabbit pAb
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.